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Verapamil-sensitive ventricular tachycardia in patients without structural heart disease. J Cardiol 77: 967973. Li GR, Feng JL, Yue LX, Carrier M, and Nattel S 1996 ; Evidence for two components of delayed rectifier K current in human ventricular myocytes. Circ Res 78: 689 696. Loussouarn G, Charpentier F, Mohammad-Panah R, Kunzelmann K, Baro I, and Escande D 1997 ; KvLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4- N-ethylsulfonyl-N-methylamino ; -3-hydroxy-2, 2-dimethylchromane. Mol Pharmacol 52: 11311136. Manouvrier J, Sagot M, Carson C, Vasklamm G, Leroy R, Reade R, and Dacloux G 1986 ; Nine cases of torsades de pointes with bepridil administration. Heart J 5: 10051007. Massie BM 1997 ; Mibefradil: a selective T-type calcium antagonist. J Cardiol 80: 231321. Napolitano C, Priori S, and Schwartz P 1994 ; Torsade de pointes: mechanism and management. Drugs 47: 51 65. Nattel S, Talajic M, Fermini B, and Roy D 1992 ; Amiodarone: pharmacology, clinical actions, and relationships between them. J Cardiovasc Electrophysiol 3: 266 280. Pancrazio JJ, Viglione MP, Kleiman RJ, and Kim YI 1991 ; Verapamil-induced blockade of voltage-activated K current in small-cell lung cancer cells. J Pharmacol Exp Ther 257: 184 191. Pinto JV, Ramani K, Neelagaru S, Kown M, and Gheorghiade M 1997 ; Amiodarone therapy in chronic heart failure and myocardial infarction: a review of the mortality trials with special attention to STAT-CHF and the GESICA trials: Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina. Prog Cardiovasc Dis 40: 8593. Rampe D, Wible B, Fedida D, Dage RC, and Brown 1993 ; Verapamil blocks a rapidly activating delayed rectifier K channel cloned from human heart. Mol Pharmacol 44: 642 648. Rauer H and Grissmer S 1996 ; Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3. Mol Pharmacol 50: 16251634. Roden DM 1996 ; Antiarrhythmic drugs, in Goodman & Gilman's The Pharmacological Basis of Therapeutics Hardman JG and Limbird LE, eds ; , 9th ed, pp 839 874, McGraw-Hill, New York. Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, and Vincent GM 1996 ; Multiple mechanisms in the long-QT syndrome: current knowledge, gaps, and future directions. Circulation 94: 1996 2012. Salata JJ and Brooks RR 1997 ; Pharmacology of azimilide dihydrochloride NE10064 ; , a class III antiarrhythmic agent. Cardiovasc Drug Rev 15: 137156. Salata JJ, Jurkiewicz NK, Jow B, Folander K, Guinosso PJ, Raynor JB, Swanson R, and Fermini B 1996 ; IK of rabbit ventricle is composed of two currents: evidence for IKs. J Physiol 271: H2477H2489. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, and Keating MT 1996 ; Coassembly of KvLQT1 and MinK IsK ; proteins to form cardiac IKs potassium channel. Nature Lond ; 384: 80 83. Sanguinetti MC, Jiang CG, Curran ME, and Keating MT 1995 ; A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81: 299 307. Sanguinetti MC and Jurkiewicz NK 1990 ; Two components of cardiac delayed rectifier K current: differential sensitivity to block by class-III antiarrhythmic agents. J Gen Physiol 96: 195215. Singh BN 1989 ; When is QT prolongation antiarrhythmic and when is it proarrhythmic? J Cardiol 63: 867 869. Snyders DJ and Chaudhary A 1996 ; High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol 49: 949 955. Waldo AL, Camm AJ, deRuyter H, Friedman PL, MacNeil DJ, Pauls JF, Pitt B, Pratt CM, and Veltri EP 1996 ; Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction: the SWORD investigators. Survival With Oral d-Sotalol. Lancet 348: 712. Yatani A, Brown AM, and Schwartz A 1986 ; Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther 237: 9 17.

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