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Tial and submitted as confidential disclosure within some defined time frame. The subject matter is simply a description of the invention or technology, e.g. "protein X expressed in cardiac cells, pertaining to University Docket #12345." The scope, purpose and limitations of use of the disclosure should also be defined. If the intended purpose of the information is to evaluate possible interest in acquiring rights to an invention, this should be stated. Further, the disclosure could be limited strictly to this evaluation role. The CDA will also contain a number of exceptions that could disqualify information from confidential status. In simple terms, the common exceptions to holding information in confidential status include: 1 ; the information being in the public domain at the time of disclosure, 2 ; the information becoming part of the public domain after disclosure, 3 ; the information was already in the receiving party's possession at the time of disclosure, 4 ; the information is received by the receiving party legally and without restriction from a third party, or 5 ; the information is independently developed by the receiving party without use or access to the confidential information. A number of additional provisions may be included in the confidentiality agreement. Some parties will request that all written materials, documents and other things made available for the purpose of the CDA be returned. In this case the receiving party is entitled to retain one copy of the material to determine its obligation under the agreement. Other sections may pertain to further rights and obligations, the former indicating that there is no implied license. This makes it clear that by signing the CDA that there are no obligations beyond providing confidential information. No further obligation means that there is no obligation to negotiate or enter in a licensing agreement. Types of Agreements There are several common types of "technology transfer" mechanisms available to the academic researcher. These include consulting, sponsored research, materials transfer, licenses and participation in consortia. When entering into negotiations for one of these agreements, it is usually preferable to address the non-financial issues first. Defining the scope of research and the non-financial terms first will help to assign the value of the agreement. These non-financial issues include confidentiality concerns, publication rights, ownership of data, performance of research and rights to improvements, as well as the more legal concerns of indemnification and warranty. Once these terms have been negotiated it is appropriate to address, as applicable, dollar amounts assigned to license fees, IP costs and research funding. The goal of the agreement negotiation for both parties is a win-win situation. The first step should be to determine what the other party needs and wants to achieve from the collaboration or deal, and try to accommodate these needs. In many instances money is not the key, and creativity in deal structure can help to get both parties what they need. Working with Your Technology Transfer Office: An Insider's Perspective Mark Bloom, Esq., Manager of Technology Licensing and Sponsored Programs and Chief Patent Counsel, The Cleveland Clinic Foundation, Cleveland, OH. Genesis of Non-Profit Organization NPO ; University Technology Transfer Activities Prior to 1968, NPO's Universities, on a case-by-case basis, had to petition the specific federal agency that funded the development of the technology in question to obtain the ability to commercially market that technology; however the ownership of the technology remained with the federal government. From 1968 to 1980, several NPOs Universities signed agency-specific agreements that allowed for the uniform treatment of commercialization efforts for technologies funded by those specific agencies; however, as before, the ownership of the technology remained with the federal government. Finally, in 1981, with the passage of the Bayh-Dole Act, NPOs Universities were able to own outright all technologies that they developed with federal monies. The Bayh-Dole Act was a watershed event in the explosive growth of NPO University technology transfer activities that has continued to the present day. Most Important Academic Technology Transfer Issues Of the myriad technology transfer issues addressed by NPO University technology transfer professionals when working with industrial partners, there are four of particular importance, namely: 1 ; Ensuring that their researchers have the freedom to publish the results of their research. 2 ; Ensuring that their researchers are given proper attribution regarding future technology developments associated with their original research efforts. 3 ; Ensuring that the role of their NPO University in the development of a technology is recognized in an equitable manner. 4 ; Ensuring that their NPO University shares equitably in the revenue generated from the commercialization of their technologies. Biggest Academic Technology Transfer Perils The conduct of technology transfer activities is not without risk to NPOs Universities. Examples of such risks include an industry partner: 1 ; Placing unreasonable restrictions on a researcher's right to publish research results, i.e., seriously impinging upon or outright preventing the exercise of academic freedom; however, short publication delay for patentability or confi continued on page 298.
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USAWOA, Lone Star Chapter meeting, April 17 The Lone Star Chapter of the United States Army Warrant Officer Association is holding a special meeting, in lieu of the regularly scheduled monthly meeting, for the Annual Installation of Officers on Saturday, April 17, 6 p.m. All active duty, retired, Reserve, National Guard and family members of current or former Warrant Officers are invited to attend. For information, call WO1 Matthew Watterson at 295-8773 or e-mail at matthew.watterson us.army l. DMRTI to host course June 21-25 The Defense Medical Readiness Training Institute will host the Homeland Security Medical Executive Course at the Hilton Austin Airport in Austin, Texas. Course information is available at dmrti.army l. Purple Heart veterans sought Purple Heart Veterans are invited to join the meeting of Military Order of the Purple Heart on the first Saturday of every month, 9 a.m. at the Roadrunner Community Center to learn more about combat related entitlements and claims benefits. Registration begins at 9 a.m. Bring your DD For 214 and a short biography. FSH Sergeants Major Association seeks new members The Fort Sam Houston Sergeants Major Association meets every third Thursday of the month, 6 p.m. in the FSH NCO Club. Retired Sgt. Maj. Howard T. Ray, president of the association, extends a cordial invitation to all Active Duty and retired command sergeants major, sergeants major and master sergeants on the promotion list from all service branches to attend the meetings. For information, call Sgt. Maj. Hector Viczaino at 221-7305. Calling all single Soldiers to join BOSS The Better Opportunities for Single Soldiers meetings are held on the first and third Wednesday of every month, 1: 30 p.m. at the Hacienda Recreation Center. The BOSS committee was established to provide Soldier input to the commander, who uses the committee's recommendations to improve single Soldiers' Morale, Welfare and Recreation programs. For information, call BOSS President Kimberly Vaughan at 916-1772 or BOSS Program Manager Ben Paniagua at 224-7250.
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Evidence has emerged that many of the `great' names of the time were influenced by romantic philosophy.1 There were many differing and contradictory shades of romantic thought at that time.8 Lenoir argues that between the extremes of vitalism biological forms and forces are subject to their own rules, distinct and not dependant on those governing the inorganic world ; and reductionism all biological phenomena can be explained by physical laws and forces ; , many scientists chose a doctrine that took the middle road, allowing for both the separation and interaction of the biological and physical worlds. These scientists worked within a philosophy of biology outlined by Immanuel Kant 1724-1804 ; . In his Critique of Judgement published in 1790, Kant argues that the concept of cause and effect can and should be used when studying events that take place in the inorganic world, as consequences tend to follow one another in a linear sequence. Problems arise when applying this view to the organic world as cause and effect are linked. A tree causes leaves to grow on it yet the leaves also cause the tree to grow; in Kant's words, "An organised natural product is one in which every part is reciprocally both ends and means".9 In order to escape this paradox, he suggests that when studying events in nature one must assume that natural phenomena have an innate purposefulness. This assumption however, must remain just that, an assumption to help guide enquiry, and one must be careful not to make the logically inconsistent leap that nature really is purposeful. For Kant the paradox of investigating biologACNR VOLUME 3 NUMBER 1 MARCH APRIL 2003.
Taormina, A. November 2005 ; . "Overview of SCI specific to nursing and Shepherd Center's rehabilitation process." Georgia State University, Student Nurse Association Meeting. Atlanta, GA. Tefertiller, C. and Backus, D. March 2006 ; . "Activity Based Therapies: Current Practice and Future Trends." Shepherd Center Annual SCI Conference. Atlanta, GA. Tefertiller, C. September 2006 ; . "Clinical experience with patients who have undergone OMA olfactory mucosal autograft ; cell transplantation procedure." Florence, Italy. Thrower, B. October 2005 ; . "Visiting Professor Lecture Series for CME." North Caroline Healthcare Providers. Charlotte, NC. Thrower, B. June 2005 ; . "Pilot Study of 250 vs. 500 mcg of IFN-1b in RRMS." Consortium of MS Centers Annual Meeting. Orlando, FL. Thrower, B. June 2005 ; . "Relapse Management in MS." Consortium of MS Centers Annual Meeting. Orlando, FL. Ulicny, G.R. March 2005 ; . "How the currently existing payment systems can or cannot promote appropriateness of care." Do the Right Thing: The Appropriation in Rehabilitative Medicine Conference. Farrara, Italy. VanHiel, L.R. & Marcus, D. August 2006 ; . "Research at Shepherd Center." Annual Conference for Case Managers. Atlanta, GA. VanHiel, L.R., Sonenblum, S., Sprigle, S., Maurer, C., & Lin, C-J. June 2005 ; . "Kinematic study of depression transfers in SCI using motion capture technology." RESNA Annual Conference. Atlanta, GA. VanHiel, L.R., Clesson, I. & Apple, D. F. February 2005 ; . "Experimental procedures for acute spinal cord injuries." 4th Annual Georgia Trauma Association Conference. Atlanta, GA. Ventresca, J. & Depel, C. May 2005 ; . "MS and exercise after an attack." Georgia Chapter of the MS Support Group. Atlanta, GA. Wallace, T.D. March 2006 ; . "Learn to thrive on challenge and change: Living with brain injury." Regional Medical Center. Memphis, TN. Wallace, T.D., Shisler Marshall, R., & Laures-Gore, J. November 2006 ; . "Functional communication and aphasia: The impact of group intervention." ASHA 2006 National Convention: Using Evidence to Support Clinical Practice. San Diego, CA. Wallace, T.D., Ninesling, N. November 2005 ; . "Executive Functions and Traumatic Brain Injury." 12th Annual Brain Injury Educational Conference: Innovative Clinical Practices: Brain Injury Association of FL. Coral Springs, Fl. Wallace, T.D. March 2005 ; . "Group treatment and aphasia: Implementation to outcomes." 2005 Georgia Speech-Language-Hearing Association State Convention. Macon, GA. Weaver, K., Daviou, P. & Backus, D. November 2006 ; . "The benefits of an activity-based approach for individuals with high tetraplegia." Howard H. Steel Conference on Injuries and Dysfunction of the Spinal Cord in Children. Buena Vista, FL and bidil.
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35 74. Yang, G., Timme, T.L., Frolov, A., Wheeler, T.M., and Thompson, T.C. 2005 ; Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression. Cancer, 103, 1186-1194. 75. Persad, S., Attwell, S., Gray, V., Delcommenne, M., Troussard, A., Sanghera, J., and Dedhar, S. 2000 ; Inhibition of integrin-linked kinase ILK ; suppresses activation of protein kinase B Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc.Natl.Acad i.U.S.A, 97, 3207-3212. 76. von Mensdorff-Pouilly, S., Snijdewint, F.G., Verstraeten, A.A., Verheijen, R.H., and Kenemans, P. 2000 ; Human MUC1 mucin: a multifaceted glycoprotein. Int.J.Biol.Markers, 15, 343-356. 77. Bryden, A.A., Hoyland, J.A., Freemont, A.J., Clarke, N.W., Schembri, W.D., and George, N.J. 2002 ; Ecadherin and beta-catenin are down-regulated in prostatic bone metastases. BJU.Int., 89, 400-403. 78. Chen, L.M., Zhang, X., and Chai, K.X. 2004 ; Regulation of prostasin expression and function in the prostate. Prostate, 59, 1-12. 79. Bandyopadhyay, S., Pai, S.K., Hirota, S., Hosobe, S., Tsukada, T., Miura, K., Takano, Y., Saito, K., Commes, T., Piquemal, D., Watabe, M., Gross, S., Wang, Y., Huggenvik, J., and Watabe, K. 2004 ; PTEN upregulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. Cancer Res., 64, 76557660. 80. Bubendorf, L., Kolmer, M., Kononen, J., Koivisto, P., Mousses, S., Chen, Y., Mahlamaki, E., Schraml, P., Moch, H., Willi, N., Elkahloun, A.G., Pretlow, T.G., Gasser, T.C., Mihatsch, M.J., Sauter, G., and Kallioniemi, O.P. 1999 ; Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J.Natl ncer Inst., 91, 1758-1764. 81. Sirotnak, F.M., She, Y., Khokhar, N.Z., Hayes, P., Gerald, W., and Scher, H.I. 2004 ; Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events. Mol rcinog., 41, 150-163. 82. Karan, D., Kelly, D.L., Rizzino, A., Lin, M.F., and Batra, S.K. 2002 ; Expression profile of differentiallyregulated genes during progression of androgen-independent growth in human prostate cancer cells. Carcinogenesis, 23, 967-975. 83. Zhou, J.R., Yu, L., Zerbini, L.F., Libermann, T.A., and Blackburn, G.L. 2004 ; Progression to androgenindependent LNCaP human prostate tumors: cellular and molecular alterations. Int ncer, 110, 800-806. 84. Oosterhoff, J.K., Grootegoed, J.A., and Blok, L.J. 2005 ; Expression profiling of androgen-dependent and -independent LNCaP cells: EGF versus androgen signalling. Endocr.Relat Cancer, 12, 135-148. 85. Calvo, A., Xiao, N., Kang, J., Best, C.J., Leiva, I., Emmert-Buck, M.R., Jorcyk, C., and Green, J.E. 2002 ; Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Res., 62, 53255335. 86. Miller, G.J., Miller, H.L., van, B.A., Lambert, J.R., Werahera, P.N., Schirripa, O., Lucia, M.S., and Nordeen, S.K. 2003 ; Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Res., 63, 5879-5888.
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Coverage of Non-Sedating Antihistamines Brand non-sedating antihistamine drugs are paid as Tier 3, regardless of the drug's formulary status of preferred or non-preferred drug. For example, if you prefer to take the medication Clarinex rather than buying Claritin over the counter, you will pay the Tier 3 copayment. Retail Refill Limit The Prescription Drug Program will maintain a Retail Refill Limit policy. The retail refill limit requires that you use the mail-order pharmacy if you are prescribed a maintenance medication, rather than refilling multiple prescriptions for the same drug at a retail pharmacy. If you or a covered dependent receives a prescription for a maintenance medication and you do not use the mailorder pharmacy, your prescriptions may not be covered. In some circumstances, you may not be required to use the mail-order pharmacy. For example, there are several categories of medications that are uniquely appropriate for multiple refills at your local pharmacy and are therefore exempt from the mandatory mail-order provision, as outlined above ; . If you have a prescription for any of the following medications, the Prescription Drug Program allows you to receive multiple refills at your local retail pharmacy: Anti-infectives, including antibiotics Amoxicillin, Biaxin ; , antivirals Zovirax, Famvir ; , antifungals Diflucan ; , and drops used in the eyes and ears Polsporin Opth, Cipro Otic ; . Please note that drops must be prescribed specifically to treat infection. For example, glaucoma drops are not covered. Prescription cough medications, including Phenergan with Codeine, Tessalon, and Tussionex and bilberry.
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The proposed TMDL was developed using Monte Carlo Simulation to determine long-term average concentrations that each stream segment could accept and still meet water quality criteria 99% of the time. Monte Carlo Simulation allows for the expansion of a data set based on its statistical makeup. Since there was no critical flow condition where criteria were exceeded, the Department used the average flow to express the loading values in the proposed TMDL. The proposed TMDL for the Laurel Run Watershed sets allowable loading rates for metals and acidity at specified points in the watershed. Field data was used to establish the proposed TMDL for the Laurel Run Watershed. The data and all supporting information used to develop the proposed TMDL are available from the Department. The Department will accept written comments on the proposed TMDL for the Laurel Run Watershed. All written comments must be postmarked by March 21, 2007, and sent to Scott Barnes, P. G., Department of Environmental Protection, Moshannon District Mining Office, 186 Enterprise Drive, Philipsburg, PA 16866, 814 ; 342-8200, or scbarnes state.pa . To request a copy of the proposed TMDL and associated information sheet or to obtain directions to the Moshannon District Mining Office, please contact Scott Barnes at the phone number or e-mail address indicated previously. The proposed TMDL for the Laurel Run Watershed can be accessed through the Department's website at dep ate.pa DEP Keyword: TMDL ; . Persons with a disability who require accommodations to attend this meting should contact the Department at 814 ; 472-1900 or the Pennsylvania AT&T Relay Service at 800 ; 6545984 TDD users ; or 800 ; 654-5988 voice users ; to discuss how the Department may accommodate their needs and betaseron.
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